Brief Report on Scientific Research, 2015-2016

  • Topic 1: Research on Chemical Composition and Inhibitory effect some Cancer Cell Lines of Heliteres hirsuta Loureiro

    Le Thi Hai Yen; Nguyen Thi Nga; Nguyen Thi Quyen;

    Pham Thi Hang Nga; Luu Thi Bich Ngoc

    This research, we have identified in the extract of Helicteres hirsuta Lour. from Binh Phuoc – Viet Nam have glucose, terpenoid, coumarin, tanin and flavonoid. Total polyphenol content of galic acid in the sample calculated as 0.3667% dried. Segment chloroform extraction from Helicteres hirsuta Lour. have the strong effect of inhibiting some cancer cell:  KB (IC50 = 9.22 µg/ml); (Hep G2 IC50 = 15.7µg/ml);  LU-1 (IC50 = 11.2 µg/ml), weak effect on MCF-7 (IC50 = 78.7 µg/ml).

    Keywords: Helicteres hirsuta Lour.; inhibiting cancer cell; KB; Hep G2; LU-1, MCF-7.


    Topic 2:Reseach on Advantages of BMD Liquid Extraction Against Constipation and on Hard Capsule Production

    Ma Thi Hong Nga, Nguyen Thi Hoa Hien,

    Vu Thi Phuong Thao, Nguyen Thi Lan Anh;
    Nguyen Thi Huong

    BMD liquid extraction which is made from medical herbs such as Sophora japonica, Angelica sinensis, Houttuynia cordata, studied to be good for Hemorrhoids treatment. We produce BMD liquid extraction, establish basic standards, check quality base on these basic standards. The extraction with basic standards will be collected to study its advantages againts constipation and to produce hard capsules.

    The fisrt benifit of BMD liquid extraction is against ex vivo constipation, carried on isolatated rabit’s bowel at different concentraction. The result is that: the frequency increasing and the changes of bowel’s movement at 0,125% and 0,0625% are clearly shown (p<0,001) especially at 0,0625%. When studying BMD liquid extraction’s antagonistic aspect acts against atropin on isolated bowel’s movement of rabit we see that: frequency and amplitude of bowel’s movement rise evidently higher than before (p<0,001) as we use BMD liquid extraction at 0,0625% for the first time. There frequency and amplitude are effected to decrease by atropin lower than before, especially compare with the use of BMD at 0,0625 for the first time (p<0,001). Frequency and amplitude are to increase when using BMD liquid extraction at 0,0625% for the second time higher than using atropin (p<0,001).

    The second benefit is to produce hard capsules. We study and establish a formula of hard capsules which includes BMD solid extraction (325mg), calci carbonat (65mg), cassava starch (247mg), magnesi stearat (6,5mg), talc (6,5mg) and a producing process with method of rubbing wet seeds. In addition, basic standard with half complete product in seed type and hard capsules are given in the research. Theses products which have been made, are also checked by applying this basic standard.


    Topic 3: Research on Liver Protective and Antixiodant Effects of An Xoa Liquid (Helicteres hirsuta Loureiro) in Experiment

    Vu Thi Minh Hien; Nguyen Thi Thanh Ha; Nguyen Huu Quan;

    Nguyen Thi Ngoc Anh; Nguyen Thi Anh Trang

    In this study, we evaluated the protective effect on liver and antioxidant of Helicteres hirsuta Loureiro through model: quantitative change in the activity of AST, ALT, MDA in mice liver after causing paracetamol poisoning.

    The results showed that Helicteres hirsuta Loureiro dose of 24g/kg have a protective effect on liver as decreasing activity of AST, ALT, limiting the damage to both the structure and behavior of mice liver caused by paracetamol with dose of 300mg/kg. Helicteres hirsuta Loureiro high dose of 24g/kg showed better effect than dose 12g/kg. Both doses of Helicteres hirsuta Loureiro have antioxidant effect by reducing MDA of liver.


    Topic 4: Research and Images Characteristics Several Factors Related to Brain Bleeding Loss in CT 64 and 256 Slice

    Le Thi Thuy Lan, Cao Van Chinh,

    Tien Thi Nga, Nguyen Viet Ha

    Brain bleeding accounts for 10-15% of cases of stroke (Rhart, 1994), bleeding in the brain with the mortality rate from 27% to 64.5%, 38% of patients live more than five brain hemorrhage the fưst and often severe sequelae of motor spirit. Intraventricular bleeding complications is a life-threatening neurological patients, hence the need to be diagnosed early, apply the timely treatment. Today, imaging techniques is grovving, such as CT scan multi-range, magnetic resonance imaging and cerebral angiography is digitized background erase the diagnosis and fmd the cause intraventricular bleeding becomes easier. In the CT scan which is the leading method in assessments intraventricular bleeding Purpose: Characterization intraventricular bleeding pictures and Initially identiTied a number of factors related to intraventricular bleeding on CT 64 slice and 256 slice.Material and methods:52 patients were diagnosed by intraventricular bleeding not-CT Scanner brain injury on 64 or 256 slice, taken CT Scanner cerebrovascular on 64 slice or 256 slice not and Inịection Contrast at the Department Radiology of Bach Mai Hospital - 8 /2014- 2 /2016. Results:Intraventricular bleeding is a medical emergency patients, the most common age group 50- 69 (67.31%). Diseases common in men than in women (ratio 3/1) .For primary location of hematoma is the most common parenchymal hippocampus, the Central gray (55.55%), brain lobes (41.66 %) .For intraventricular blood where the most common is the occipital homs of the ventricles (90.37%), intraventricular four (30.76%), isrontal hom (28.64%). the size hematoma more large, poor prognosis, the risk the higher the proportion of the poor prognosis size small hematoma (16.67%), average (33,33%), large (50%). Intraventricular bleeding degree as much risk as high prognosis, poor prognosis rate: Level I (11.43%), level II (18.18%), level III (33.33%). Flowing primary intraventricular blood ratio better prognosis secondary intraventricular bleeding. Cause intraventricular bleeding is the most common due to hypertension (high blood pressure alone (16.33%), and hypertension in collaboration with other causes (51.9%), then to the aneurysm ( 34.69%). intraventricular bleeding in people under 50 years of age, the cause is often due to vascular malíbrmations (30%), in people aged 50 years and older brain aneurysm (34.69%) and hypertension (increased simple blood pressure and pulmonary hypertension with other causes). bleeding the thalamus and the brain's position Central gray usually caused by hypertension (25%), usually caused by brain lobes aneurysm (42.86%). Conclusion: Hematoma size larger, the risk of a poor prognosis higher. Intraventricular bleeding degree as much risk as high prognosis. Primary intraventricular bleeding rates better prognosis secondary intraventricular bleeding. Cause intraventricular bleeding is the most common hypertension due to an aneurysm then. Intraventricular bleeding in people under 50 years of age, the cause is oíten due to vascular abnormalities, in people aged 50 years and older brain aneurysm and hypertension. Bleeding in the brain and human thalamus location Central brain usually caused by hypertension, often caused by brain lobes aneurysm.


    Topic 5: Study the Stablity of the Fragment Gene Design Specific Primer for Rapid PCR Assay to Identify Group B Streptococci in Pregrant Women

    Nguyen Hong Phuc, Nguyen Thi Hong Ngoc, Bui Thu Hang,

    Nguyen Minh Hue, Nguyen Trong Tan

              The cfb gene encoding the CAMP factor was selected as the genetic target for the PCR assay to identify group B Streptococci in pregnant women from 34th to 37th weeks. The comparision of nucleotide sequence between S.agalactiae ATCC 13813 and strains. The strains were isolated from vaginal specimens showed the similarities of sequences as follows: 73,3% of the studied strains were identical with S.agalactiae ATCC 13813; 26.3 % were similar from 95,7% to 99,3% with the standard strain.


    Topic 6: Determination of the Immunization of Antibiotic of Bacteria (ESBL: Extended Spectrum β-lactamase)

    at VIET – DUC Hospital  2015-2016

    Ha Thi Nguyet Minh, Bui Huy Tung,

                                        Nguyen Thanh Huyen, Nguyen Thanh Thuy,Vu Van Hai

                Determining the percentage of antibiotic sensitivity from 115 strains ESBL isolated from 115 patients at the Department of Microbiology, Vietnam-Germany Hospital for 6 months (11/2015 to 4/2016), resulting in the 5 isolated bacteria which are mainly: E. coli majority of (73%), klebsiella  (22%), Proteus (4%), Citrobacter (0,9%), Enterobacter (0,9 %). 
                The received results revealed that: E. coli and Klebsiella were sensitive to cefoperazon + sulbactam (86.9%; 88%); Ticarcillin + clavulanate (69%; 40%); amikacin (65.4%; 40%); levofloxacin (51.2%; 36%); cefoxitin (54.8% of 72%). E. coli and Klebsiella were resistant to cefuroxime, ceftriaxon, cefotaxime, Ceftazidim (100%). The minimum inhibitory concentration (MIC) of ertapenem and imipenem 33 strains ESBL bacteria: MIC of  resistant to imipenem(≥ 4 µg/ml) with 12,1% and ertapenem (2 µg/ml) with 9.1%.


    Topic 7: Assessment of Treatment Results of Patients with Alcoholic Syndrome at Thanh Nhan Hospital

    Tran Thanh Tam, Hoang Anh Lan, Pham Van Tan,

    Vu Hong Vinh, Nguyen Thi Hue

    Circumstances, research reasons: alcohol withdrawal syndrome includes a variety of symptoms appear after drinking alcohol or taking significantly reduce the amount of alcohol than before in alcoholics. Alcohol withdrawal syndrome is a psychiatric emergency, if not treated properly will lead to a series of severe disorder with mortality rates remain high. Subjects and Methods: The controlled clinical intervention before – after study design collecting the indicators on the track treated 34 patients with alcohol withdrawal syndrome were treated at the Department of Neurology - Hospital 03/2016 09/2015 came from Serenity. Results: 100% of patients in the study group were male, mean age 48.97 ± 10.15 years old; 85.3% of patients with alcohol withdrawal syndrome from the first 2 days after stopping alcohol; the plant neurological disorders (tremor, sweating); psychiatric disorders (anxiety); movement disorders (agitation) statistically significantly reduced compared with before treatment; 3 Factors related to treatment outcome is: no pre-existing liver disease, appearing time 2 days after discontinuation of withdrawal of alcohol, patients without biochemical blood disorders, the differences are there YNTK with p-values ​​<0.05. Conclusion: the neurological disorders and mental plant significantly reduced compared with before treatment, relating to 03 key factors that have no pre-existing liver disease, time from 2 days to appear after withdrawal after discontinuation of alcohol, patients without biochemical blood disorders. Keywords: Alcohol withdrawal syndrome.


    Topic 8: Survey of Status of Depression and Related Factors in College Students Nursing Regular Medical Colleges Hanoi, 2015

    Tran Thuy Lieu; Tran ThoTuan; Ngo Thi Lien; Ngo Thi Bich Hanh; Do Cam Van

    Assessment of the status of mental health issues in medical college students. Target: Describes the rate of depression in students of Nursing College and describes some of the factors related to depression in students. The object and method of the study: Students of Nursing College, the academic year 2015-2016; the method describes the horizontal cut. Results: General depression rate: 9.3%. Students resolve difficulties by making the mind thanks to the help of his parents at risk of depression only by 0.34 times. Conclusion: The rate of depression in students of Nursing College formally Hanoi Medical College is 9.3%. To resolve difficulties by making the mind thanks to the help of my parents are identified as related to bipolar disorder depression in this study.


    Topic 9: Prevelce Stress and Related factors among Third – Year Students ò Hanoi Medical College, Year 2015-2016

    Doan Cong Khanh; Mai Thi Dung; Bui Van Dung;

    Nguyen Thi Hieu; Nguyen Hai Yen

    A cross sectional study has been conducted in Hanoi Medical College with a self-administrated questionaire on 398 third-year students. The results showed that student got stress accounetd 50.8% within both male and female participants. The results also suggested that the communication on stress is neccessary in order to promote the ability to response to stress of students.


    Topic 10: Research Reality Awareness and Practice of Nursing Students College Course 8 Internship at some Hospital in Hanoi, 2015

    Pham Thu Ha; Nguyen Thu Tra; Phuong Van Hoang;

    Nguyen Minh Phuong; Nguyen Thi Mai

    A cross sectional study has been implemented in 797 the third-year- students of nurse - Hanoi Medical College who were studying in 8 hospitals in Hanoi. A self-administrated questionare and a check-up form were used to assess their knowledge and practice related to medical ethics. The results showed that teacher and internet are the major sources provided ethics iníbrmation for the participants. Ethics knowledge and practice of students were relatively limited (62.6% and 9.9% of the participants have good knowledge and good practice respectively). Those who participated in taking care of >10 patients per day, nursing in the moming, who did not love nursing job and had limited knowledge tended to períorm medical ethics worse than those of the opposite ones (p<0,05).


    Topic 11: Knowledge and Reality Vaccination for Childen Under One Year of Social Care at Towm Thanh Liet, Thanh Tri District, Hanoi City in 2015-2016

    Quan Thi Ngat, Dang Huong Giang,

     Nguyen Le Thuy, Ha Dieu Linh, Luong Anh Vu

    This study aimed to describe the current situation and evaluate immunization caregivers' knowledge about immunization for children under 1 year old at Thanh Liet Commune, Thanh Tri District, Hanoi in 2015 - 2016. Study subjects the pair caregivers/children aged 9 months to 24 months by the time of the study. Research Methodology describe the cross. The results showed that: the proportion of children under 1 year fully vaccinated is 96%, the proportion of children being vaccinated BCG is 98%, the number of children with BCG scar standard is 98, the rate of general knowledge about caregivers has achieved immunization accounting 28%, 25% caregivers with fully vaccinated knowledge gained about.


    Topic 12: Survey of Satisfaction of Final Year Nursing Students for a Number of Field of Training Acivities in Hanoi Medicin College 2016

    Mai Thi Minh Nghia; Le Thi Thuy Quynh; Tran Vu Hoang Anh;

    Nguyen Thi Thuy Anh; Nguyen Thi Thu Trang

    Circumstances, the reason research: Survey Pupils and students’ satisfaction on a number of areas for the operation of training which is one of the important channels for College to gradually adjust the behavior in order to improve training quality. Subjects and Methods: The cross descriptive study collects research indicators in 400 final year nursing students from October to April (9/2015-4/2016). Results: The results showed that the average score of the learners’ satisfaction is not high. The percentage learers which is not happy remains at high level (79,3%). Conclusion: Pupils and students are very satisfied to teachers in charge but not satisfied with the facilities of school, especially the inter-wifi syste, hygiene of toilets, electricity devices and portable water systems. Results also showerd that there is significant influence of gender, education level, living location, learning outcomes achived on the learners’ satisfaction toward some training serveces at school.


    Topic 13: Knowledge, Attitude of Pregnant Woman Numbers obout Problem Caeserean Maternity Hospital in Hanoi Year 2015-2016

    Pham Thuy Quynh, Doan Thi Van, Tran Mai Huyen,

     Le Tung Lam, Ma Thi Hong Lien

    Goal: Describle knowledge, attitude of pregnant woman numbers obout problem caeserean maternity hospital in Hanoi year 2015-2016. Methods: describle interrupted on 368 pregnant women at antenatal third quarter Obstetrics Hospital in Hanoi from January to March 2/2016 to 11/2015. Results: In 368 women participated in the study with 19.3% of women desire to be Caesarean. Number of women with gestational age of 36 weeks in the hospital antenatal care is 74.7%. The closer to the desired date of birth Caesaean maternal higer. 64.9% of women said that more complications Caesarean birth vaginally, can affect breastfeeding problems earlier and close later than the birth vaginally with rate respectively 65.8% and 62%. However, there are still 71 women choose caesarean because of these factors: surgical pain (33.8%); afraid to suffer birth (47.9%);  Caesarean faster (35.2%); the majority of women with a strong belief in the Caesarean fasrer (70.4%); milk for slower (61.7%); choose the date and time of birth (67.1%) and the vagina is not after student (52.7%). Women do not belive in the Caesarean delivery should Smarter (60.9%) or Caesarean section is the best plan for the child (63.3%) and (62.8%) for mother. Conclude: Almost for women are knowledge pretty good about how students, benifits and sometimes even difficulties both mother and children if right Caesarean. However on field attitude difference markedly between the two groups unwanted vaginal birth and wants a Caesarean. Research needed intervention deeper increase understanding of knowledge as well as attitude on the iss Caesarean.


    Topic 14:

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